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Vinylogous reactivity of enol diazoacetates with donor-acceptor substituted hydrazones. Synthesis of substituted pyrazole derivatives.

ABSTRACT: A regiospecific synthesis of multifunctional pyrazoleshas been developed from a cascade process triggered by Rh(II)-catalyzed dinitrogen extrusion from enol diazoacetates with vinylogous nucleophilic addition followed by Lewis acid catalyzed cyclization and aromatization.

SUBMITTER: Xu X

PROVIDER: S-EPMC3574190 | biostudies-literature | 2013 Feb

REPOSITORIES: biostudies-literature

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Vinylogous reactivity of enol diazoacetates with donor-acceptor substituted hydrazones. Synthesis of substituted pyrazole derivatives.

Xu Xinfang X Zavalij Peter Y PY Hu Wenhao W Doyle Michael P MP

The Journal of organic chemistry 20130124 4

A regiospecific synthesis of multifunctional pyrazoleshas been developed from a cascade process triggered by Rh(II)-catalyzed dinitrogen extrusion from enol diazoacetates with vinylogous nucleophilic addition followed by Lewis acid catalyzed cyclization and aromatization. ...[more]

PMID: 23301562

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