Ontology highlight
ABSTRACT:
SUBMITTER: Mugoni V
PROVIDER: S-EPMC3574195 | biostudies-literature | 2013 Jan
REPOSITORIES: biostudies-literature
Cell 20130101 3
Protection against oxidative damage caused by excessive reactive oxygen species (ROS) by an antioxidant network is essential for the health of tissues, especially in the cardiovascular system. Here, we identified a gene with important antioxidant features by analyzing a null allele of zebrafish ubiad1, called barolo (bar). bar mutants show specific cardiovascular failure due to oxidative stress and ROS-mediated cellular damage. Human UBIAD1 is a nonmitochondrial prenyltransferase that synthesize ...[more]