Ontology highlight
ABSTRACT:
SUBMITTER: Thomaston JL
PROVIDER: S-EPMC3575861 | biostudies-literature | 2013 Jan
REPOSITORIES: biostudies-literature
Thomaston Jessica L JL Nguyen Phuong A PA Brown Emily C EC Upshur Mary Alice MA Wang Jun J DeGrado William F WF Howard Kathleen P KP
Protein science : a publication of the Protein Society 20121119 1
As a target of antiviral drugs, the influenza A M2 protein has been the focus of numerous structural studies and has been extensively explored as a model ion channel. In this study, we capitalize on the expanding body of high-resolution structural data available for the M2 protein to design and interpret site-directed spin-labeling electron paramagnetic resonance spectroscopy experiments on drug-induced conformational changes of the M2 protein embedded in lipid bilayers. We obtained data in the ...[more]