Ontology highlight
ABSTRACT:
SUBMITTER: Yin Z
PROVIDER: S-EPMC3575915 | biostudies-literature | 2012 Dec
REPOSITORIES: biostudies-literature
Yin Zhiqi Z Lapkouski Mikalai M Yang Wei W Craigie Robert R
Protein science : a publication of the Protein Society 20121026 12
Integrase is the key enzyme that mediates integration of retroviral DNA into cellular DNA which is essential for viral replication. Inhibitors of HIV-1 that target integrase recognize the nucleoprotein complexes formed by integrase and viral DNA substrate (intasomes) rather than the free enzyme. Atomic resolution structures of HIV-1 intasomes are therefore required to understand the mechanisms of inhibition and drug resistance. To date, prototype foamy virus (PFV) is the only retrovirus for whic ...[more]