Ontology highlight
ABSTRACT:
SUBMITTER: Hare S
PROVIDER: S-EPMC2837123 | biostudies-literature | 2010 Mar
REPOSITORIES: biostudies-literature
Hare Stephen S Gupta Saumya Shree SS Valkov Eugene E Engelman Alan A Cherepanov Peter P
Nature 20100131 7286
Integrase is an essential retroviral enzyme that binds both termini of linear viral DNA and inserts them into a host cell chromosome. The structure of full-length retroviral integrase, either separately or in complex with DNA, has been lacking. Furthermore, although clinically useful inhibitors of HIV integrase have been developed, their mechanism of action remains speculative. Here we present a crystal structure of full-length integrase from the prototype foamy virus in complex with its cognate ...[more]