Ontology highlight
ABSTRACT:
SUBMITTER: Roff AN
PROVIDER: S-EPMC3576078 | biostudies-literature | 2013 Feb
REPOSITORIES: biostudies-literature
Roff Alanna N AN Panganiban Ronaldo P RP Bond Judith S JS Ishmael Faoud T FT
The Journal of biological chemistry 20121226 7
Meprins are multimeric proteases that are implicated in inflammatory bowel disease by both genetic association studies and functional studies in knock-out mice. Patients with inflammatory bowel disease show decreased colonic expression of meprin α, although regulation of expression, particularly under inflammatory stimuli, has not been studied. The studies herein demonstrate that the human meprin α transcript is bound and stabilized by Hu antigen R at baseline, and that treatment with the inflam ...[more]