Ontology highlight
ABSTRACT:
SUBMITTER: Klement G
PROVIDER: S-EPMC3576529 | biostudies-literature | 2013 Feb
REPOSITORIES: biostudies-literature
Klement Göran G Eisele Lina L Malinowsky David D Nolting Andreas A Svensson Mats M Terp Gitte G Weigelt Dirk D Dabrowski Michael M
Biophysical journal 20130201 4
The pharmacology and regulation of Transient Receptor Potential Ankyrin 1 (TRPA1) ion channel activity is intricate due to the physiological function as an integrator of multiple chemical, mechanical, and temperature stimuli as well as differences in species pharmacology. In this study, we describe and compare the current inhibition efficacy of human TRPA1 on three different TRPA1 antagonists. We used a homology model of TRPA1 based on Kv1.2 to select pore vestibule residues available for intera ...[more]