Ontology highlight
ABSTRACT:
SUBMITTER: Bocker MT
PROVIDER: S-EPMC3576573 | biostudies-literature | 2012 May
REPOSITORIES: biostudies-literature
Bocker Michael T MT Tuorto Francesca F Raddatz Günter G Musch Tanja T Yang Feng-Chun FC Xu Mingjiang M Lyko Frank F Breiling Achim A
Nature communications 20120508
Differentiation is accompanied by extensive epigenomic reprogramming, leading to the repression of stemness factors and the transcriptional maintenance of activated lineage-specific genes. Here we use the mammalian Hoxa cluster of developmental genes as a model system to follow changes in DNA modification patterns during retinoic acid-induced differentiation. We find the inactive cluster to be marked by defined patterns of 5-methylcytosine (5mC). Upon the induction of differentiation, the active ...[more]