Ontology highlight
ABSTRACT:
SUBMITTER: Deng X
PROVIDER: S-EPMC3576853 | biostudies-literature | 2011 Oct
REPOSITORIES: biostudies-literature
Deng Xinxian X Hiatt Joseph B JB Nguyen Di Kim DK Ercan Sevinc S Sturgill David D Hillier LaDeana W LW Schlesinger Felix F Davis Carrie A CA Reinke Valerie J VJ Gingeras Thomas R TR Shendure Jay J Waterston Robert H RH Oliver Brian B Lieb Jason D JD Disteche Christine M CM
Nature genetics 20111023 12
Many animal species use a chromosome-based mechanism of sex determination, which has led to the coordinate evolution of dosage-compensation systems. Dosage compensation not only corrects the imbalance in the number of X chromosomes between the sexes but also is hypothesized to correct dosage imbalance within cells that is due to monoallelic X-linked expression and biallelic autosomal expression, by upregulating X-linked genes twofold (termed 'Ohno's hypothesis'). Although this hypothesis is well ...[more]