Ontology highlight
ABSTRACT:
SUBMITTER: Cheng LE
PROVIDER: S-EPMC3576928 | biostudies-literature | 2013 Jan
REPOSITORIES: biostudies-literature
Immunity 20130103 1
Mast cells are tissue-resident immune cells that play a central role in allergic disease. These contributions are largely dependent on the acquisition of antigen-specific immunoglobulin E (IgE). Despite this requirement, studies of mast cell and IgE interactions have overlooked the mechanism by which mast cells acquire IgE from the blood. To address this gap, we developed reporter IgE molecules and employed imaging techniques to study mast cell function in situ. Our data demonstrate that skin ma ...[more]