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Perivascular dendritic cells elicit anaphylaxis by relaying allergens to mast cells via microvesicles.


ABSTRACT: Anaphylactic reactions are triggered when allergens enter the blood circulation and activate immunoglobulin E (IgE)-sensitized mast cells (MCs), causing systemic discharge of prestored proinflammatory mediators. As MCs are extravascular, how they perceive circulating allergens remains a conundrum. Here, we describe the existence of a CD301b+ perivascular dendritic cell (DC) subset that continuously samples blood and relays antigens to neighboring MCs, which vigorously degranulate and trigger anaphylaxis. DC antigen transfer involves the active discharge of surface-associated antigens on 0.5- to 1.0-micrometer microvesicles (MVs) generated by vacuolar protein sorting 4 (VPS4). Antigen sharing by DCs is not limited to MCs, as neighboring DCs also acquire antigen-bearing MVs. This capacity of DCs to distribute antigen-bearing MVs to various immune cells in the perivascular space potentiates inflammatory and immune responses to blood-borne antigens.

SUBMITTER: Choi HW 

PROVIDER: S-EPMC6376486 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature

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Perivascular dendritic cells elicit anaphylaxis by relaying allergens to mast cells via microvesicles.

Choi Hae Woong HW   Suwanpradid Jutamas J   Kim Il Hwan IH   Staats Herman F HF   Haniffa Muzlifah M   MacLeod Amanda S AS   Abraham Soman N SN  

Science (New York, N.Y.) 20181101 6415


Anaphylactic reactions are triggered when allergens enter the blood circulation and activate immunoglobulin E (IgE)-sensitized mast cells (MCs), causing systemic discharge of prestored proinflammatory mediators. As MCs are extravascular, how they perceive circulating allergens remains a conundrum. Here, we describe the existence of a CD301b<sup>+</sup> perivascular dendritic cell (DC) subset that continuously samples blood and relays antigens to neighboring MCs, which vigorously degranulate and  ...[more]

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