Ontology highlight
ABSTRACT:
SUBMITTER: Choi HW
PROVIDER: S-EPMC6376486 | biostudies-literature | 2018 Nov
REPOSITORIES: biostudies-literature
Choi Hae Woong HW Suwanpradid Jutamas J Kim Il Hwan IH Staats Herman F HF Haniffa Muzlifah M MacLeod Amanda S AS Abraham Soman N SN
Science (New York, N.Y.) 20181101 6415
Anaphylactic reactions are triggered when allergens enter the blood circulation and activate immunoglobulin E (IgE)-sensitized mast cells (MCs), causing systemic discharge of prestored proinflammatory mediators. As MCs are extravascular, how they perceive circulating allergens remains a conundrum. Here, we describe the existence of a CD301b<sup>+</sup> perivascular dendritic cell (DC) subset that continuously samples blood and relays antigens to neighboring MCs, which vigorously degranulate and ...[more]