Ontology highlight
ABSTRACT:
SUBMITTER: Carta M
PROVIDER: S-EPMC3579137 | biostudies-literature | 2013 Feb
REPOSITORIES: biostudies-literature
Carta Mario M Opazo Patrizio P Veran Julien J Athané Axel A Choquet Daniel D Coussen Françoise F Mulle Christophe C
The EMBO journal 20130104 4
Calmodulin-dependent kinase II (CaMKII) is key for long-term potentiation of synaptic AMPA receptors. Whether CaMKII is involved in activity-dependent plasticity of other ionotropic glutamate receptors is unknown. We show that repeated pairing of pre- and postsynaptic stimulation at hippocampal mossy fibre synapses induces long-term depression of kainate receptor (KAR)-mediated responses, which depends on Ca(2+) influx, activation of CaMKII, and on the GluK5 subunit of KARs. CaMKII phosphorylati ...[more]