Ontology highlight
ABSTRACT:
SUBMITTER: Steller EJ
PROVIDER: S-EPMC3579322 | biostudies-literature | 2013 Feb
REPOSITORIES: biostudies-literature
Steller Ernst J A EJ Raats Danielle A DA Koster Jan J Rutten Bert B Govaert Klaas M KM Emmink Benjamin L BL Snoeren Nikol N van Hooff Sander R SR Holstege Frank C P FC Maas Coen C Borel Rinkes Inne H M IH Kranenburg Onno O
Neoplasia (New York, N.Y.) 20130201 2
In epithelial tumors, the platelet-derived growth factor receptor B (PDGFRB) is mainly expressed by stromal cells of mesenchymal origin. Tumor cells may also acquire PDGFRB expression following epithelial-to-mesenchymal transition (EMT), which occurs during metastasis formation. Little is known about PDGFRB signaling in colorectal tumor cells. We studied the relationship between PDGFRB expression, EMT, and metastasis in human colorectal cancer (CRC) cohorts by analysis of gene expression profile ...[more]