Ontology highlight
ABSTRACT:
SUBMITTER: Teng S
PROVIDER: S-EPMC6951341 | biostudies-literature | 2020 Jan
REPOSITORIES: biostudies-literature
Cell research 20191206 1
Metastasis, the development of secondary malignant growths at a distance from a primary tumor, is the cause of death for 90% of cancer patients, but little is known about how metastatic cancer cells adapt to and colonize new tissue environments. Here, using clinical samples, patient-derived xenograft (PDX) samples, PDX cells, and primary/metastatic cell lines, we discovered that liver metastatic colorectal cancer (CRC) cells lose their colon-specific gene transcription program yet gain a liver-s ...[more]