Dataset Information

Long-term changes in adiposity and glycemic control are associated with past adenovirus infection.

ABSTRACT:

Objective

Ad36, a human adenovirus, increases adiposity but improves glycemic control in animal models. Similarly, natural Ad36 infection is cross-sectionally associated with greater adiposity and better glycemic control in humans. This study compared longitudinal observations in indices of adiposity (BMI and body fat percentage) and glycemic control (fasting glucose and insulin) in Ad36-infected versus uninfected adults.

Research design and methods

Baseline sera from Hispanic men and women (n = 1,400) were screened post hoc for the presence of Ad36-specific antibodies. Indices of adiposity and glycemic control at baseline and at ~10 years past the baseline were compared between seropositive and seronegative subjects, with adjustment for age and sex. In addition to age and sex, indices of glycemic control were adjusted for baseline BMI and were analyzed only for nondiabetic subjects.

Results

Seropositive subjects (14.5%) had greater adiposity at baseline, compared with seronegative subjects. Longitudinally, seropositive subjects showed greater adiposity indices but lower fasting insulin levels. Subgroup analyses revealed that Ad36-seropositivity was associated with better baseline glycemic control and lower fasting insulin levels over time in the normal-weight group (BMI ?25 kg/m(2)) and longitudinally, with greater adiposity in the overweight (BMI 25-30 kg/m(2)) and obese (BMI >30 kg/m(2)) men. Statistically, the differences between seropositive and seronegative individuals were modest in light of the multiple tests performed.

Conclusions

This study strengthens the plausibility that in humans, Ad36 increases adiposity and attenuates deterioration of glycemic control. Panoptically, the study raises the possibility that certain infections may modulate obesity or diabetes risk. A comprehensive understanding of these under-recognized factors is needed to effectively combat such metabolic disorders.

SUBMITTER: Lin WY

PROVIDER: S-EPMC3579356 | biostudies-literature | 2013 Mar

REPOSITORIES: biostudies-literature

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Publications

Long-term changes in adiposity and glycemic control are associated with past adenovirus infection.

Lin Wan-Yu WY Dubuisson Olga O Rubicz Rohina R Liu Nianjun N Allison David B DB Curran Joanne E JE Comuzzie Anthony G AG Blangero John J Leach Charles T CT Göring Harald H Dhurandhar Nikhil V NV

Diabetes care 20121116 3

<h4>Objective</h4>Ad36, a human adenovirus, increases adiposity but improves glycemic control in animal models. Similarly, natural Ad36 infection is cross-sectionally associated with greater adiposity and better glycemic control in humans. This study compared longitudinal observations in indices of adiposity (BMI and body fat percentage) and glycemic control (fasting glucose and insulin) in Ad36-infected versus uninfected adults.<h4>Research design and methods</h4>Baseline sera from Hispanic men ...[more]

PMID: 23160725

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Project description:Background The risk of surgical site infection has been reported to be higher in patients with poorly controlled diabetes. Since chronic hyperglycemia impairs neutrophil functions, preoperative glycemic control may restore neutrophil function. However, long-term insulin therapy may lead to a delay in surgery, which may be a problem, especially in cancer surgery. It is therefore unfortunate that there have been few studies in which the optimal duration of perioperative glycemic control for diabetes with chronic hyperglycemia was investigated. Therefore, we investigated the effects of preoperative long-term insulin therapy and short-term insulin therapy on perioperative neutrophil functions in diabetic mice with chronic hyperglycemia. Methods Five-week-old male C57BL/6?J mice were divided into four groups (No insulin (Diabetes Mellitus: DM), Short-term insulin (DM), Long-term insulin (DM), and Non-diabetic groups). Diabetes was established by administrating repeated low-dose streptozotocin. The Short-term insulin (DM) group received insulin therapy for 6?h before the operation and the Long-term insulin (DM) group received insulin therapy for 5?days before the operation. The No insulin (DM) group and the Non-diabetic group did not receive insulin therapy. At 14?weeks of age, abdominal surgery with intestinal manipulation was performed in all four groups. We carried out a phagocytosis assay with fluorescent microspheres and a reactive oxygen species (ROS) production assay with DCFH-DA (2?,7?-dichlorodihydrofluorescein diacetate) before and 24?h after the operation using FACSVerse™ with BD FACSuite™ software. Results Blood glucose was lowered by insulin therapy in the Short-term insulin (DM) and Long-term insulin (DM) groups before the operation. Neutrophilic phagocytosis activities before and after the operation were significantly restored in the Long-term insulin (DM) group compared with those in the No insulin (DM) group (before: p?=?0.0008, after: p?=?0.0005). However, they were not significantly restored in the Short-term insulin (DM) group. Neutrophilic ROS production activities before and after the operation were not restored in either the Short-term insulin (DM) group or Long-term insulin (DM) group. Conclusions Preoperative and postoperative phagocytosis activities are restored by insulin therapy for 5?days before the operation but not by insulin therapy for 6?h before the operation.

Dataset Information

Long-term changes in adiposity and glycemic control are associated with past adenovirus infection.

Objective

Research design and methods

Results

Conclusions

Publications

Long-term changes in adiposity and glycemic control are associated with past adenovirus infection.

Similar Datasets

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