Ontology highlight
ABSTRACT:
SUBMITTER: Nguyen TH
PROVIDER: S-EPMC3579505 | biostudies-literature | 2013 Mar
REPOSITORIES: biostudies-literature
Nguyen Thi H TH Kim Sung-Hye SH Decker Caitlin G CG Wong Darice Y DY Loo Joseph A JA Maynard Heather D HD
Nature chemistry 20130217 3
Basic fibroblast growth factor (bFGF) is a protein that plays a crucial role in diverse cellular functions, from wound healing to bone regeneration. However, a major obstacle to the widespread application of bFGF is its inherent instability during storage and delivery. Here, we describe the stabilization of bFGF by covalent conjugation with a heparin-mimicking polymer, a copolymer consisting of styrene sulfonate units and methyl methacrylate units bearing poly(ethylene glycol) side chains. The b ...[more]