Ontology highlight
ABSTRACT:
SUBMITTER: Wei D
PROVIDER: S-EPMC3580125 | biostudies-literature | 2013 Jan
REPOSITORIES: biostudies-literature
Wei DengGuo D Wilson W David WD Neidle Stephen S
Journal of the American Chemical Society 20130116 4
High-resolution crystal structures of the DNA duplex sequence d(CGCGAATTCGCG)(2) complexed with three minor-groove ligands are reported. A highly conserved cluster of 11 linked water molecules has been found in the native and all 3 ligand-bound structures, positioned at the boundary of the A/T and G/C regions where the minor groove widens. This cluster appears to play a key structural role in stabilizing noncovalently binding small molecules in the AT region of the B-DNA minor groove. The cluste ...[more]