MicroRNA-7 regulates the mTOR pathway and proliferation in adult pancreatic ?-cells.
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ABSTRACT:
SUBMITTER: Wang Y
PROVIDER: S-EPMC3581216 | biostudies-literature | 2013 Mar
REPOSITORIES: biostudies-literature
Publications
MicroRNA-7 regulates the mTOR pathway and proliferation in adult pancreatic β-cells.
Wang You Y Liu Jiangying J Liu Chengyang C Naji Ali A Stoffers Doris A DA
Diabetes 20121206 3
Elucidating the mechanism underlying the poor proliferative capacity of adult pancreatic β-cells is critical to regenerative therapeutic approaches for diabetes. Here, we show that the microRNA (miR)-7/7ab family member miR-7a is enriched in mouse adult pancreatic islets compared with miR-7b. Remarkably, miR-7a targets five components of the mTOR signaling pathway. Further, inhibition of miR-7a activates mTOR signaling and promotes adult β-cell replication in mouse primary islets, which can be r ...[more]
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