Ontology highlight
ABSTRACT:
SUBMITTER: Lomniczi A
PROVIDER: S-EPMC3581714 | biostudies-literature | 2013 Mar
REPOSITORIES: biostudies-literature
Lomniczi Alejandro A Loche Alberto A Castellano Juan Manuel JM Ronnekleiv Oline K OK Bosch Martha M Kaidar Gabi G Knoll J Gabriel JG Wright Hollis H Pfeifer Gerd P GP Ojeda Sergio R SR
Nature neuroscience 20130127 3
The timing of puberty is controlled by many genes. The elements coordinating this process have not, however, been identified. Here we show that an epigenetic mechanism of transcriptional repression times the initiation of female puberty in rats. We identify silencers of the Polycomb group (PcG) as principal contributors to this mechanism and show that PcG proteins repress Kiss1, a puberty-activating gene. Hypothalamic expression of two key PcG genes, Eed and Cbx7, decreased and methylation of th ...[more]