Ontology highlight
ABSTRACT:
SUBMITTER: Wen X
PROVIDER: S-EPMC3581944 | biostudies-literature | 2013 Feb
REPOSITORIES: biostudies-literature
Wen Xiangshu X Rao Ping P Carreño Leandro J LJ Kim Seil S Lawrenczyk Agnieszka A Porcelli Steven A SA Cresswell Peter P Yuan Weiming W
Proceedings of the National Academy of Sciences of the United States of America 20130204 8
Despite a high degree of conservation, subtle but important differences exist between the CD1d antigen presentation pathways of humans and mice. These differences may account for the minimal success of natural killer T (NKT) cell-based antitumor therapies in human clinical trials, which contrast strongly with the powerful antitumor effects in conventional mouse models. To develop an accurate model for in vivo human CD1d (hCD1d) antigen presentation, we have generated a hCD1d knock-in (hCD1d-KI) ...[more]