Ontology highlight
ABSTRACT:
SUBMITTER: Xi Q
PROVIDER: S-EPMC3582033 | biostudies-literature | 2011 Dec
REPOSITORIES: biostudies-literature
Xi Qiaoran Q Wang Zhanxin Z Zaromytidou Alexia-Ileana AI Zhang Xiang H-F XH Chow-Tsang Lai-Fong LF Liu Jing X JX Kim Hyesoo H Barlas Afsar A Manova-Todorova Katia K Kaartinen Vesa V Studer Lorenz L Mark Willie W Patel Dinshaw J DJ Massagué Joan J
Cell 20111201 7
Specific chromatin marks keep master regulators of differentiation silent yet poised for activation by extracellular signals. We report that nodal TGF-β signals use the poised histone mark H3K9me3 to trigger differentiation of mammalian embryonic stem cells. Nodal receptors induce the formation of companion Smad4-Smad2/3 and TRIM33-Smad2/3 complexes. The PHD-Bromo cassette of TRIM33 facilitates binding of TRIM33-Smad2/3 to H3K9me3 and H3K18ac on the promoters of mesendoderm regulators Gsc and Mi ...[more]