Ontology highlight
ABSTRACT:
SUBMITTER: Verzi MP
PROVIDER: S-EPMC3554120 | biostudies-literature | 2013 Jan
REPOSITORIES: biostudies-literature
Verzi Michael P MP Shin Hyunjin H San Roman Adrianna K AK Liu X Shirley XS Shivdasani Ramesh A RA
Molecular and cellular biology 20121105 2
Tissue-specific gene expression requires modulation of nucleosomes, allowing transcription factors to occupy cis elements that are accessible only in selected tissues. Master transcription factors control cell-specific genes and define cellular identities, but it is unclear if they possess special abilities to regulate cell-specific chromatin and if such abilities might underlie lineage determination and maintenance. One prevailing view is that several transcription factors enable chromatin acce ...[more]