Ontology highlight
ABSTRACT:
SUBMITTER: Wei PC
PROVIDER: S-EPMC3582359 | biostudies-literature | 2012 Dec
REPOSITORIES: biostudies-literature
Wei Pei-Chi PC Hsieh Yi-Hsuan YH Su Mei-I MI Jiang Xianzhi X Hsu Pang-Hung PH Lo Wen-Ting WT Weng Jui-Yun JY Jeng Yung-Ming YM Wang Ju-Ming JM Chen Phang-lang PL Chang Yi-Cheng YC Lee Kuo-Fen KF Tsai Ming-Daw MD Shew Jin-Yuh JY Lee Wen-Hwa WH
Molecular cell 20121101 5
NPGPx is a member of the glutathione peroxidase (GPx) family; however, it lacks GPx enzymatic activity due to the absence of a critical selenocysteine residue, rendering its function an enigma. Here, we show that NPGPx is a newly identified stress sensor that transmits oxidative stress signals by forming the disulfide bond between its Cys57 and Cys86 residues. This oxidized form of NPGPx binds to glucose-regulated protein (GRP)78 and forms covalent bonding intermediates between Cys86 of NPGPx an ...[more]