Ontology highlight
ABSTRACT:
SUBMITTER: Mehta AP
PROVIDER: S-EPMC3582411 | biostudies-literature | 2013 Feb
REPOSITORIES: biostudies-literature
Mehta Angad P AP Hanes Jeremiah W JW Abdelwahed Sameh H SH Hilmey David G DG Hänzelmann Petra P Begley Tadhg P TP
Biochemistry 20130204 7
MoaA, a radical S-adenosylmethionine enzyme, catalyzes the first step in molybdopterin biosynthesis. This reaction involves a complex rearrangement in which C8 of guanosine triphosphate is inserted between C2' and C3' of the ribose. This study identifies the site of initial hydrogen atom abstraction by the adenosyl radical and advances a mechanistic proposal for this unprecedented reaction. ...[more]