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The CoFactor database: organic cofactors in enzyme catalysis.

ABSTRACT:

Motivation

Organic enzyme cofactors are involved in many enzyme reactions. Therefore, the analysis of cofactors is crucial to gain a better understanding of enzyme catalysis. To aid this, we have created the CoFactor database.

Results

CoFactor provides a web interface to access hand-curated data extracted from the literature on organic enzyme cofactors in biocatalysis, as well as automatically collected information. CoFactor includes information on the conformational and solvent accessibility variation of the enzyme-bound cofactors, as well as mechanistic and structural information about the hosting enzymes.

Availability

The database is publicly available and can be accessed at http://www.ebi.ac.uk/thornton-srv/databases/CoFactor.

SUBMITTER: Fischer JD

PROVIDER: S-EPMC2944199 | biostudies-literature | 2010 Oct

REPOSITORIES: biostudies-literature

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Publications

The CoFactor database: organic cofactors in enzyme catalysis.

Fischer Julia D JD Holliday Gemma L GL Thornton Janet M JM

Bioinformatics (Oxford, England) 20100802 19

<h4>Motivation</h4>Organic enzyme cofactors are involved in many enzyme reactions. Therefore, the analysis of cofactors is crucial to gain a better understanding of enzyme catalysis. To aid this, we have created the CoFactor database.<h4>Results</h4>CoFactor provides a web interface to access hand-curated data extracted from the literature on organic enzyme cofactors in biocatalysis, as well as automatically collected information. CoFactor includes information on the conformational and solvent a ...[more]

PMID: 20679331

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