Ontology highlight
ABSTRACT:
SUBMITTER: Freeman AK
PROVIDER: S-EPMC3582845 | biostudies-literature | 2013 Feb
REPOSITORIES: biostudies-literature
Freeman Alyson K AK Ritt Daniel A DA Morrison Deborah K DK
Molecular cell 20130124 4
Raf kinases are essential for normal Ras-Raf-MEK-ERK pathway signaling, and activating mutations in components of this pathway are associated with a variety of human cancers, as well as the related developmental disorders Noonan, LEOPARD, and cardiofaciocutaneous syndromes. Although the Raf kinases are known to dimerize during normal and disease-associated Raf signaling, the functional significance of Raf dimerization has not been fully elucidated. Here, using mutational analysis and a peptide i ...[more]