Ontology highlight
ABSTRACT:
SUBMITTER: Shao J
PROVIDER: S-EPMC3582999 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Scientific reports 20130101
Nanotechnology has been extensively explored for drug delivery. Here, we introduce the concept of a nanodrug based on synergy of photothermally-activated physical and biological effects in nanoparticle-drug conjugates. To prove this concept, we utilized tumor necrosis factor-alpha coated gold nanospheres (Au-TNF) heated by laser pulses. To enhance photothermal efficiency in near-infrared window of tissue transparency we explored slightly ellipsoidal nanoparticles, its clustering, and laser-induc ...[more]