Ontology highlight
ABSTRACT:
SUBMITTER: Cao E
PROVIDER: S-EPMC3583019 | biostudies-literature | 2013 Feb
REPOSITORIES: biostudies-literature
Neuron 20130201 4
The capsaicin receptor, TRPV1, is regulated by phosphatidylinositol-4,5-bisphosphate (PIP(2)), although the precise nature of this effect (i.e., positive or negative) remains controversial. Here, we reconstitute purified TRPV1 into artificial liposomes, where it is gated robustly by capsaicin, protons, spider toxins, and, notably, heat, demonstrating intrinsic sensitivity of the channel to both chemical and thermal stimuli. TRPV1 is fully functional in the absence of phosphoinositides, arguing a ...[more]