Ontology highlight
ABSTRACT:
SUBMITTER: Wang F
PROVIDER: S-EPMC3583435 | biostudies-literature | 2012 Apr
REPOSITORIES: biostudies-literature
Wang Fan F Zhou Haiyan H Yang Yuzhen Y Xia Xiumei X Sun Qian Q Luo Jin J Cheng Bin B
Oncology reports 20120103 4
Hepatitis B virus X protein (HBx) plays a crucial role in the development of hepatocellular carcinoma (HCC), however, little is known about the mechanism. Here, we investigated the relationship between HBx and Notch signaling in HepG2 cells after they were transfected with the HBx gene. It was found that HBx upregulated the expression of Notch-1, Jagged-1 and Hes-1 at the transcriptional level by binding to the Notch-1 intracellular dom ...[more]