Ontology highlight
ABSTRACT:
SUBMITTER: Saha SK
PROVIDER: S-EPMC7210388 | biostudies-literature | 2020 Jun
REPOSITORIES: biostudies-literature
Saha Subbroto Kumar SK Choi Hye Yeon HY Yang Gwang-Mo GM Biswas Polash Kumar PK Kim Kyeongseok K Kang Geun-Ho GH Gil Minchan M Cho Ssang-Goo SG
Molecular therapy oncolytics 20200414
Hepatocellular carcinoma (HCC) is a leading cause of cancer-related death worldwide, and it is thus critical to identify novel molecular biomarkers of HCC prognosis and elucidate the molecular mechanisms underlying HCC progression. Here, we show that G-protein-coupled receptor 50 (<i>GPR50</i>) in HCC is overexpressed and that <i>GPR50</i> knockdown may downregulate cancer cell progression through attenuation of the Notch signaling pathway. <i>GPR50</i> knockdown was found to reduce HCC progress ...[more]