Ontology highlight
ABSTRACT:
SUBMITTER: Jiang LI
PROVIDER: S-EPMC3583495 | biostudies-literature | 2013 Mar
REPOSITORIES: biostudies-literature
Jiang Lily I LI Wang Jennifer E JE Sternweis Paul C PC
Molecular pharmacology 20121210 3
Regulation of multiple adenylyl cyclases (AC) provides unique inputs to mediate the synthesis of cAMP, a ubiquitous second messenger that controls many aspects of cellular function. On stimulation by G(s), the activities of ACs can be further selectively modulated by other pathways to ensure precise control of intracellular cAMP responses to specific stimuli. Recently, we reported that one of the AC isoforms, AC7, is uniquely regulated by the G(13) pathway. To understand more fully the molecular ...[more]