Ontology highlight
ABSTRACT:
SUBMITTER: Hines LM
PROVIDER: S-EPMC6674903 | biostudies-literature | 2006 Nov
REPOSITORIES: biostudies-literature
Hines Lisa M LM Hoffman Paula L PL Bhave Sanjiv S Saba Laura L Kaiser Alan A Snell Larry L Goncharov Igor I LeGault Lucie L Dongier Maurice M Grant Bridget B Pronko Sergey S Martinez Larry L Yoshimura Masami M Tabakoff Boris B
The Journal of neuroscience : the official journal of the Society for Neuroscience 20061101 48
Major depression represents a complex mental disorder. The identification of biological markers that define subtypes of major depressive disorder would greatly facilitate appropriate medical treatments, as well as provide insight into etiology. Reduced activity of the cAMP signaling system has been implicated in the etiology of major depression. Previous work has shown low adenylyl cyclase activity in platelets and postmortem brain tissue of depressed individuals. Here, we investigate the role o ...[more]