Ontology highlight
ABSTRACT:
SUBMITTER: Cao L
PROVIDER: S-EPMC3583731 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Cao Lu L Li Chunguang C Shen Shuwen S Yan Yan Y Ji Weidan W Wang Jinghan J Qian Haihua H Jiang Xiaoqing X Li Zhigang Z Wu Mengchao M Zhang Ying Y Su Changqing C
BMC cancer 20130222
<h4>Background</h4>OCT4 and BIRC5 are preferentially expressed in human cancer cells and mediate cancer cell survival and tumor maintenance. However, the molecular mechanism that regulates OCT4 and BIRC5 expression is not well characterized.<h4>Methods</h4>By manipulating OCT4 and BIRC5 expression in hepatocellular carcinoma (HCC) cell lines, the regulatory mechanism of OCT4 on BIRC5 and CCND1 were investigated.<h4>Results</h4>Increasing or decreasing OCT4 expression could enhance or suppress BI ...[more]