Ontology highlight
ABSTRACT:
SUBMITTER: Nie M
PROVIDER: S-EPMC7053608 | biostudies-literature | 2020 Jan
REPOSITORIES: biostudies-literature
Nie Min M Wang Yadong Y Yu Zenong Z Li Xinyu X Deng Yexuan Y Wang Ying Y Yang Dongjun D Li Qixiang Q Zeng Xiangwei X Ju Junyi J Liu Ming M Zhao Quan Q
Aging 20200125 2
Aurora kinase B (AURKB) triggers the phosphorylation of serine 10 on histone H3 (H3S10ph), which is important for chromosome condensation and cytokinesis during mitosis in mammals. However, how exactly AURKB controls cell cycle and contributes to tumorigenesis as an oncoprotein under pathological conditions remains largely unknown. Here, we report that AURKB promotes gastric cancer cell proliferation <i>in vitro</i> and <i>in vivo</i>. Silencing AURKB expression inhibits gastric cell proliferati ...[more]