Ontology highlight
ABSTRACT:
SUBMITTER: Versteeg GA
PROVIDER: S-EPMC3584420 | biostudies-literature | 2013 Feb
REPOSITORIES: biostudies-literature
Versteeg Gijs A GA Rajsbaum Ricardo R Sánchez-Aparicio Maria Teresa MT Maestre Ana M AM Valdiviezo Julio J Shi Mude M Inn Kyung-Soo KS Fernandez-Sesma Ana A Jung Jae J García-Sastre Adolfo A
Immunity 20130201 2
Innate immunity conferred by the type I interferon is critical for antiviral defense. To date only a limited number of tripartite motif (TRIM) proteins have been implicated in modulation of innate immunity and anti-microbial activity. Here we report the complementary DNA cloning and systematic analysis of all known 75 human TRIMs. We demonstrate that roughly half of the 75 TRIM-family members enhanced the innate immune response and that they do this at multiple levels in signaling pathways. More ...[more]