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Substrate recognition by TRIM and TRIM-like proteins in innate immunity.

ABSTRACT: TRIM (Tripartite motif) and TRIM-like proteins have emerged as an important class of E3 ligases in innate immunity. Their functions range from activation or regulation of innate immune signaling pathway to direct detection and restriction of pathogens. Despite the importance, molecular mechanisms for many TRIM/TRIM-like proteins remain poorly characterized, in part due to challenges of identifying their substrates. In this review, we discuss several TRIM/TRIM-like proteins in RNA sensing pathways and viral restriction functions. We focus on those containing PRY-SPRY, the domain most frequently used for substrate recognition, and discuss emerging mechanisms that are commonly utilized by several TRIM/TRIM-like proteins to tightly control their interaction with the substrates.

SUBMITTER: Wang HT

PROVIDER: S-EPMC7572318 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature

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Substrate recognition by TRIM and TRIM-like proteins in innate immunity.

Wang Hai-Tao HT Hur Sun S

Seminars in cell & developmental biology 20201020

TRIM (Tripartite motif) and TRIM-like proteins have emerged as an important class of E3 ligases in innate immunity. Their functions range from activation or regulation of innate immune signaling pathway to direct detection and restriction of pathogens. Despite the importance, molecular mechanisms for many TRIM/TRIM-like proteins remain poorly characterized, in part due to challenges of identifying their substrates. In this review, we discuss several TRIM/TRIM-like proteins in RNA sensing pathway ...[more]

PMID: 33092958

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