Functional plasticity in the type IV secretion system of Helicobacter pylori.
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ABSTRACT:
SUBMITTER: Barrozo RM
PROVIDER: S-EPMC3585145 | biostudies-literature | 2013 Feb
REPOSITORIES: biostudies-literature
Publications
Functional plasticity in the type IV secretion system of Helicobacter pylori.
Barrozo Roberto M RM Cooke Cara L CL Hansen Lori M LM Lam Anna M AM Gaddy Jennifer A JA Johnson Elizabeth M EM Cariaga Taryn A TA Suarez Giovanni G Peek Richard M RM Cover Timothy L TL Solnick Jay V JV
PLoS pathogens 20130228 2
Helicobacter pylori causes clinical disease primarily in those individuals infected with a strain that carries the cytotoxin associated gene pathogenicity island (cagPAI). The cagPAI encodes a type IV secretion system (T4SS) that injects the CagA oncoprotein into epithelial cells and is required for induction of the pro-inflammatory cytokine, interleukin-8 (IL-8). CagY is an essential component of the H. pylori T4SS that has an unusual sequence structure, in which an extraordinary number of dire ...[more]
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2015-09-01 | GSE56791 | GEO
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