Ontology highlight
ABSTRACT:
SUBMITTER: Fabian AK
PROVIDER: S-EPMC3585324 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Fabian Anne-Katrin AK März Andreas A Neimanis Sonja S Biondi Ricardo M RM Kozany Christian C Hausch Felix F
PloS one 20130228 2
The FK506-binding protein 51 (FKBP51) is an Hsp90-associated co-chaperone which regulates steroid receptors and kinases. In pancreatic cancer cell lines, FKBP51 was shown to recruit the phosphatase PHLPP to facilitate dephosphorylation of the kinase Akt, which was associated with reduced chemoresistance. Here we show that in addition to FKBP51 several other members of the FKBP family bind directly to Akt. FKBP51 can also form complexes with other AGC kinases and mapping studies revealed that FKB ...[more]