FKBPs and the Akt/mTOR pathway.
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ABSTRACT:
SUBMITTER: Hausch F
PROVIDER: S-EPMC3841315 | biostudies-literature | 2013 Aug
REPOSITORIES: biostudies-literature
Publications
FKBPs and the Akt/mTOR pathway.
Hausch Felix F Kozany Christian C Theodoropoulou Marily M Fabian Anne-Katrin AK
Cell cycle (Georgetown, Tex.) 20130701 15
FK506-binding proteins (FKBP) belong to the immunophilin family and are best known for their ability to enable the immunosuppressive properties of FK506 and rapamycin. For rapamycin, this is achieved by inducing inhibitory ternary complexes with the kinase mTOR. The essential accessory protein for this gain-of-function was thought to be FKBP12. We recently showed that this view might be too restricted, since larger FK506-binding proteins can functionally substitute for FKBP12 in mammalian cells. ...[more]
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