Ontology highlight
ABSTRACT:
SUBMITTER: Bottcher T
PROVIDER: S-EPMC3585461 | biostudies-literature | 2013 Feb
REPOSITORIES: biostudies-literature
Böttcher Thomas T Kolodkin-Gal Ilana I Kolter Roberto R Losick Richard R Clardy Jon J
Journal of the American Chemical Society 20130218 8
Biofilms are often associated with human bacterial infections, and the natural tolerance of biofilms to antibiotics challenges treatment. Compounds with antibiofilm activity could become useful adjuncts to antibiotic therapy. We used norspermidine, a natural trigger for biofilm disassembly in the developmental cycle of Bacillus subtilis , to develop guanidine and biguanide compounds with up to 20-fold increased potency in preventing biofilm formation and breaking down existing biofilms. These c ...[more]