Ontology highlight
ABSTRACT:
SUBMITTER: Reyes JR
PROVIDER: S-EPMC6417427 | biostudies-literature | 2018 Nov
REPOSITORIES: biostudies-literature
Angewandte Chemie (International ed. in English) 20181102 47
The cytochalasans are a large family of polyketide natural products with potent bioactivities. Amongst them, the aspochalasins show particularly intricate and fascinating structures. To gain insight into their structural diversity and innate reactivity, we have developed a rapid synthesis of aspochalasin D, the central member of the family. It proceeded in 13 steps starting from divinyl carbinol and utilized a high pressure Diels-Alder reaction that features high regio- and stereoselectivity. So ...[more]