Ontology highlight
ABSTRACT:
SUBMITTER: Jan TA
PROVIDER: S-EPMC3585657 | biostudies-literature | 2013 Mar
REPOSITORIES: biostudies-literature
Jan Taha Adnan TA Chai Renjie R Sayyid Zahra Nabi ZN van Amerongen Renée R Xia Anping A Wang Tian T Sinkkonen Saku Tapani ST Zeng Yi Arial YA Levin Jared Ruben JR Heller Stefan S Nusse Roel R Cheng Alan Gi-Lun AG
Development (Cambridge, England) 20130301 6
Permanent hearing loss is caused by the irreversible damage of cochlear sensory hair cells and nonsensory supporting cells. In the postnatal cochlea, the sensory epithelium is terminally differentiated, whereas tympanic border cells (TBCs) beneath the sensory epithelium are proliferative. The functions of TBCs are poorly characterized. Using an Axin2(lacZ) Wnt reporter mouse, we found transient but robust Wnt signaling and proliferation in TBCs during the first 3 postnatal weeks, when the number ...[more]