Ontology highlight
ABSTRACT:
SUBMITTER: Shravage BV
PROVIDER: S-EPMC3585664 | biostudies-literature | 2013 Mar
REPOSITORIES: biostudies-literature
Shravage Bhupendra V BV Hill Jahda H JH Powers Christine M CM Wu Louisa L Baehrecke Eric H EH
Development (Cambridge, England) 20130213 6
Atg6 (beclin 1 in mammals) is a core component of the Vps34 complex that is required for autophagy. Beclin 1 (Becn1) functions as a tumor suppressor, and Becn1(+/-) tumors in mice possess elevated cell stress and p62 levels, altered NF-κB signaling and genome instability. The tumor suppressor function of Becn1 has been attributed to its role in autophagy, and the potential functions of Atg6/Becn1 in other vesicle trafficking pathways for tumor development have not been considered. Here, we gener ...[more]