Ontology highlight
ABSTRACT:
SUBMITTER: Chan CH
PROVIDER: S-EPMC3586339 | biostudies-literature | 2012 May
REPOSITORIES: biostudies-literature
Chan Chia-Hsin CH Li Chien-Feng CF Yang Wei-Lei WL Gao Yuan Y Lee Szu-Wei SW Feng Zizhen Z Huang Hsuan-Ying HY Tsai Kelvin K C KK Flores Leo G LG Shao Yiping Y Hazle John D JD Yu Dihua D Wei Wenyi W Sarbassov Dos D Hung Mien-Chie MC Nakayama Keiichi I KI Lin Hui-Kuan HK
Cell 20120501 5
Akt kinase plays a central role in cell growth, metabolism, and tumorigenesis. The TRAF6 E3 ligase orchestrates IGF-1-mediated Akt ubiquitination and activation. Here, we show that Akt ubiquitination is also induced by activation of ErbB receptors; unexpectedly, and in contrast to IGF-1 induced activation, the Skp2 SCF complex, not TRAF6, is a critical E3 ligase for ErbB-receptor-mediated Akt ubiquitination and membrane recruitment in response to EGF. Skp2 deficiency impairs Akt activation, Glut ...[more]