Ontology highlight
ABSTRACT:
SUBMITTER: Desai RA
PROVIDER: S-EPMC3586560 | biostudies-literature | 2011 May
REPOSITORIES: biostudies-literature
Desai Ravi A RA Khan Mohammed K MK Gopal Smitha B SB Chen Christopher S CS
Integrative biology : quantitative biosciences from nano to macro 20110204 5
While it is well known that individual integrins are critical mediators of cell behavior, recent work has shown that when multiple types of integrins simultaneously engage the ECM, cell functions are enhanced. However, it is not known how integrins spatially coordinate to regulate cell adhesion because no reliable method exists to segregate integrins on the cell membrane. Here, we use a microcontact printing-based strategy to pattern multiple ECMs that bind distinct integrins in order to study h ...[more]