Structural and Physicochemical Aspects of Dasatinib Hydrate and Anhydrate phases.
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ABSTRACT:
SUBMITTER: Roy S
PROVIDER: S-EPMC3586737 | biostudies-literature | 2012 Apr
REPOSITORIES: biostudies-literature
Publications
Structural and Physicochemical Aspects of Dasatinib Hydrate and Anhydrate phases.
Roy Saikat S Quiñones Rosalynn R Matzger Adam J AJ
Crystal growth & design 20120313 4
Crystal structures for the commercial monohydrate form and an anhydrate form of dasatinib, an oral anti-cancer agent, are presented along with characterization by Raman spectroscopy, powder X-ray diffraction, differential scanning calorimetry, and thermogravimetric analysis. Solubility measurements conducted in water reveal the anhydrate has dramatically improved solubility compared to the commercial hydrate form. Finally, dasatinib is a rare example of a promiscuous solvate former and the basis ...[more]
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