Ontology highlight
ABSTRACT:
SUBMITTER: Tanaka SS
PROVIDER: S-EPMC3587611 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Tanaka Satomi S SS Nakane Akihiro A Yamaguchi Yasuka L YL Terabayashi Takeshi T Abe Takaya T Nakao Kazuki K Asashima Makoto M Steiner Kirsten A KA Tam Patrick P L PP Nishinakamura Ryuichi R
PloS one 20130304 3
Dullard/Ctdnep1 is a member of the serine/threonine phosphatase family of the C-terminal domain of eukaryotic RNA polymerase II. Embryos lacking Dullard activity fail to form primordial germ cells (PGCs). In the mouse, the formation of PGCs is influenced by BMP4 and WNT3 activity. Although Dullard is reputed to negatively regulate BMP receptor function, in this study we found mutations in Dullard had no detectable effect on BMP4 and p-Smad activity. Furthermore Dullard mutations did not influenc ...[more]