Ontology highlight
ABSTRACT:
SUBMITTER: Senft AD
PROVIDER: S-EPMC6403387 | biostudies-literature | 2019 Mar
REPOSITORIES: biostudies-literature
Senft Anna D AD Bikoff Elizabeth K EK Robertson Elizabeth J EJ Costello Ita I
Nature communications 20190306 1
The essential roles played by Nodal and Bmp signalling during early mouse development have been extensively documented. Here we use conditional deletion strategies to investigate functional contributions made by Nodal, Bmp and Smad downstream effectors during primordial germ cell (PGC) development. We demonstrate that Nodal and its target gene Eomes provide early instructions during formation of the PGC lineage. We discover that Smad2 inactivation in the visceral endoderm results in increased nu ...[more]