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Stable polymorph of morphine.


ABSTRACT: In the stable polymorph of the title compound, C17H19NO3 [systematic name: (5?,6?)-7,8-didehydro-4,5-ep-oxy-17-methyl-morphinan-3,6-diol], the mol-ecular conformation is in agreement with the characteristics of previously reported morphine forms. The molecule displays the typical T-shape and its piperidine ring adopts a slightly distorted chair conformation. Inter-molecular O-H?O hydrogen bonds link the mol-ecules into helical chains parallel to the b axis. Intra-molecular O-H?O hydrogen bonds are also observed.

SUBMITTER: Gelbrich T 

PROVIDER: S-EPMC3588323 | biostudies-literature | 2013 Jan

REPOSITORIES: biostudies-literature

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Stable polymorph of morphine.

Gelbrich Thomas T   Braun Doris E DE   Griesser Ulrich J UJ  

Acta crystallographica. Section E, Structure reports online 20121205 Pt 1


In the stable polymorph of the title compound, C17H19NO3 [systematic name: (5α,6α)-7,8-didehydro-4,5-ep-oxy-17-methyl-morphinan-3,6-diol], the mol-ecular conformation is in agreement with the characteristics of previously reported morphine forms. The molecule displays the typical T-shape and its piperidine ring adopts a slightly distorted chair conformation. Inter-molecular O-H⋯O hydrogen bonds link the mol-ecules into helical chains parallel to the b axis. Intra-molecular O-H⋯O hydrogen bonds a  ...[more]

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