Ontology highlight
ABSTRACT:
SUBMITTER: Virostko J
PROVIDER: S-EPMC3590285 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Virostko John J Radhika Armandla A Poffenberger Greg G Dula Adrienne N AN Moore Daniel J DJ Powers Alvin C AC
PloS one 20130306 3
We generated a mouse model (MIP-Luc-VU-NOD) that enables non-invasive bioluminescence imaging (BLI) of beta cell loss during the progression of autoimmune diabetes and determined the relationship between BLI and disease progression. MIP-Luc-VU-NOD mice displayed insulitis and a decline in bioluminescence with age which correlated with beta cell mass, plasma insulin, and pancreatic insulin content. Bioluminescence declined gradually in female MIP-Luc-VU-NOD mice, reaching less than 50% of the ini ...[more]